邹懿，博士，星际xj娱乐官方官网“含弘英才岗”教授，博士生导师。
Yi Zou, Ph.D., “Han Hong Outstanding Talent” professor, doctoral supervisor, Southwest University
国家海外高层次引进人才计划青年项目（2018）。重庆市学术技术带头人（2019）。重庆市教育系统优秀共产党员（2019）。重庆市杰出青年基金获得者（2020）。重庆市青年专家工作室领衔专家（2021）。星际xj娱乐官方官网“十三五”科研工作先进个人（2021）。星际xj娱乐官方官网十佳青年（2022）。
He is the recipient of Overseas High-level Talent Introduction Plan of China (2018), Academic and Technical Leader of Chongqing (2019), Outstanding Communist Party Member of Chongqing Education System (2019), recipient of the Distinguished Young Scientist Fund of Chongqing (2020), Lead Expert in the Youth Expert Studio of Chongqing (2021), Advanced Individual in Scientific Research Work during the "Thirteenth Five-Year Plan" at Southwest University (2021) and Top Ten Young Scholars at Southwest University (2022).
2002-2009年于星际xj娱乐官方官网|【中国】有限公司，分别获制药工程学士和微生物与生化药学硕士学位。2013年于上海交通大学微生物代谢国家重点实验室获微生物学博士学位，研究方向为链霉菌来源的复杂结构天然产物生物合成，博士学位论文获上海市优秀博士学位论文奖。2014年-2017年，在美国加州大学洛杉矶分校（UCLA）从事博士后研究工作，研究方向为真菌来源的复杂结构天然产物酶学合成和催化机理。2017年7月，通过星际xj娱乐官方官网“聚贤工程”人才引进加入星际xj娱乐官方官网任职。近几年来，以通讯作者或第一作者身份在包括Chem. Rev., Nat. Chem. Biol., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Catal., Org. Lett., Acta. Pharm. Sin. B.等国际著名期刊上发表文章数篇，相关成果入选web of science高被引论文，被权威综述性杂志Nat. Prod. Rep.遴选为年度研究热点报道，同时被生物医学论文评价系统F1000 Prime评为杰出论文而被强烈推荐。
Between 2002 and 2009, he obtained a Bachelor's degree in Pharmaceutical Engineering and a Master's degree in Microbiology and Biochemical Pharmacy at College of Pharmaceutical Sciences, Southwest University. In 2013, He earned Ph.D in Microbiology from the State Key Laboratory of Microbial Metabolism at Shanghai Jiao Tong University. His research is focus on the biosynthesis of complex natural products derived from actinomycetes, and His Ph.D. thesis was selected as the Shanghai Outstanding Doctoral Dissertation Award. From 2014 to 2017, he worked as a postdoctoral researcher at the University of California, Los Angeles (UCLA), researching the enzyme catalytic mechanisms of complex natural products from fungi. In July 2017, he joined College of Pharmaceutical Sciences at Southwest University as part of the "Ju Xian Project" talent recruitment program. Recent years, he has published a series of articles as corresponding or first authors in prestigious journals, including Chem. Rev., Nat. Chem. Biol., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Catal., Org. Lett., and Acta. Pharm. Sin. B. His research findings have been selected as highly cited papers in the Web of Science, selected many times as the “Hot off the press” in Nat. Prod. Rep., and strongly recommended as outstanding papers by F1000 Prime.
热忱欢迎有志于真菌天然药物合成生物学与生物酶催化机理研究的
青年教师、博士后、研究生和本科生加入课题组！
Welcome to young faculty members, postdoctoral researchers, graduate students, and undergraduate students who are enthusiastic about research in fungal natural product biosynthesis and enzyme catalytic mechanisms to join our research group!
联系方式
E-mail: zouyi31@swu.edu.cn
Contact Information
E-mail: zouyi31@swu.edu.cn
教育与工作经历
2017. 06 - 至今 星际xj娱乐官方官网，星际xj娱乐官方官网，教授，博士生导师
2014. 01 - 2017. 01 加州大学洛杉矶分校，化学与分子生物工程学院，博士后
2009. 09 - 2013. 12 上海交通大学，微生物代谢国家重点实验室，微生物学，博士
2006. 09 - 2009. 06 星际xj娱乐官方官网，星际xj娱乐官方官网，微生物与生化药学，硕士
2002. 09 - 2006. 06 星际xj娱乐官方官网，星际xj娱乐官方官网，制药工程，学士
Education and Professional Experience
2017. 06 - Present, Professor, Doctoral Supervisor, College of Pharmaceutical Sciences, Southwest University
2014. 01 - 2017. 01, Postdoctoral Researcher, School of Chemistry and Molecular Bioengineering, University of California, Los Angeles
2009. 09 - 2013. 12, Ph.D. in Microbiology, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University
2006. 09 - 2009. 06, Master in Microbiology and Biochemical Pharmacy, College of Pharmaceutical Sciences, Southwest University
2002. 09 - 2006. 06, Bachelor in Pharmaceutical Engineering, College of Pharmaceutical Sciences, Southwest University
课题组研究方向
1. 真菌天然药物生物合成与酶催化机理
2. 真菌天然药物合成生物学与分子创新
Research Interests
1. Fungal Natural Product Biosynthesis and Enzyme Catalytic Mechanisms
2. Fungal Natural Product Synthetic Biology and Molecular Innovation
课题组承担的课题
1. 国家自然科学基金委面上项目（2022. 01-2025. 12，22177093）
2. 国家自然科学基金委面上项目（2019. 01-2022. 12，31870022）
3. 科技部重点研发计划合成生物学重点专项子课题（2020. 11-2025. 10，2020YFA0907700）
4. 国家海外高层次引进人才计划青年项目（A类资助）
5. 重庆市生物医药研发重大专项课题（2023. 01-2025. 12，CSTB2022TIAD-STX0015）
6. 重庆市杰出青年科学基金项目（2020. 09-2023. 08，cstc2020jcyj-jqX0005）
7. 重庆市职工创新创业计划重点项目（2018. 01-2020. 12，cx2018006）
8. 星际xj娱乐官方官网自然科学领域校级青年领军团队项目（2023.07-2026.07，SWU-XJLJ202306）
9. 星际xj娱乐官方官网2035先导计划发展培育项目（2022. 06-2025. 05，SWU-XDPY22009）
10. 中央高校业务费重点项目（2018. 04-2019. 12，XDJK2018B035）
11. 星际xj娱乐官方官网“聚贤工程”人才启动基金（2017. 07-2020. 12，SWU117034）
Research Projects
1. National Natural Science Foundation of China (2022.01-2025.12, 22177093)
2. National Natural Science Foundation of China (2019.01-2022.12, 31870022)
3. Key Subproject of the National Key R&D Program of China (2020.11-2025.10, 2020YFA0907700)
4. Overseas High-level Talent Introduction Plan of China (Category A)
5. Science and Technology Innovation Key R&D Program of Chongqing (2023.01-2025.12, CSTB2022TIAD-STX0015)
6. Chongqing Science Funds for Distinguished Young Scientists (2020.09-2023.08, cstc2020jcyj-jqX0005)
7. the Venture & Innovation Support Program for Chongqing Overseas Returnees (2018.01-2020.12, cx2018006)
8. Young Leading Team Project in the Field of Natural Sciences of Southwest University (2023.07-2026.07, SWU-XJLJ202306)
9. Special Fund for Youth Team and 2035 Pilot Plan for Innovative Research of Southwest University (2022.06-2025.05, SWU-XDPY22009)
10. Key Project fund for Central University (2018.04-2019.12, XDJK2018B035)
11. the Scientific Research Starting Foundation of Southwest University (2017.07-2020.12, SWU117034)
学术机构任职
1. 中国菌物学会药用真菌专业委员会，副主任委员
2.《药学学报》中英文两刊青年编委
3.《Green Synthesis & Catalysis》青年编委
4.《Chinese Journal of Natural Medicines》青年编委
Academic Positions in Institutions
1. Deputy Director of the Medicinal Fungi Professional Committee of the Mycological Society of China
2. Youth Editorial Board Member of "Acta Pharmaceutica Sinica B"
3. Youth Editorial Board Member of "Green Synthesis & Catalysis"
4. Youth Editorial Board Member of "Chinese Journal of Natural Medicines"
论文发表
Selected Publications:
Chem Rev, 2017
Nat Chem Biol, 2017
Nat Commun, 2022a; 2022b
J Am Chem Soc, 2022; 2020; 2015
Angew Chem Int Ed, 2023; 2019; 2013
ACS Catal, 2021
Acta Pharm Sin B, 2019
Org Lett, 2023; 2021; 2019; 2014
Complete List:
@ 独立建组以来的工作 (Since establishing independence in SWU)：
1. Yuan, G-Y., Zhang, J-M., Xu, Q-D., Zhang, H-R., Hu, C-H.*, Zou, Y.* Biosynthesis of Cosmosporasides Reveals the Assembly Line for Fungal Hybrid Terpenoid Saccharides. Angew. Chem. Int. Ed. 2023, 62, e202308887.
2. Zhang, H-R.#, Huang, Y-T.#, Tang, Y.-J., Kong, D-K.*, Zou, Y.* Genome Mining of Multi-substituted Alkylresorcinols from a Hybrid Highly Reducing- and Type III- Polyketide Pathway. Chin. Chem. Lett. 2023, DOI: 10.1016/j.cclet.2023.108968. (#co-first author)
3. Rao, L., Yuan G-Y., Chen, X-Y., Ran, J-L., Zou, Y.* Reshaping the Diversity of Oxidized Polyquinane Sesquiterpenoids by Cytochrome P450s. Org. Lett. 2023, 25, 3276-3280.
4. Chen, X-W., Rao, L., Chen, J-L., Zou, Y.* Unexpected Assembly Machinery for 4(3H)-Quinazolinone Scaffold Synthesis. Nat. Commun. 2022, 13: 6522.
5. Rao, L.#, Shi, H-C.#, Zou, Y.* A Fungal Nonribosomal Peptide-Polyketide Hybrid Synthase Synthesizes 2-Pyrrolidinone Alkaloid. Tetrahedron. 2022, 125: 133060. (#co-first author, Special Issue entitled “Frontiers in biosynthesis”, Invited Paper; Hot off the Press, Nat. Prod. Rep., 2022,39, 2209-2214.)
6. Wei, Q.#, Wang, Z-P.#, Zhang, X.*, Zou, Y.* Diaryl Ether Formation by a Versatile Thioesterase Domain. J. Am. Chem. Soc. 2022, 144, 9554-9558. (#co-first author, Highlighted by ChemistryViews; Hot off the Press, Nat. Prod. Rep., 2022, 39, 1539-1543.)
7. Zhang, J-M.#, Liu, X.#, Wei, Q., Ma, C-T., Li, D-H., Zou, Y.* Berberine Bridge Enzyme-like Oxidase-Catalysed Double Bond Isomerization Acts as the Pathway Switch in Cytochalasin Synthesis. Nat. Commun. 2022, 13: 225. (#co-first author)
8. Cai, Y., Rao, L., Zou, Y.* Genome Mining Discovery of a C4‑Alkylated Dihydroisocoumarin Pathway in Fungi. Org. Lett. 2021, 23, 2337-2341.
9. Wei, Q., Zeng, H-C., Zou, Y.* Divergent Biosynthesis of Fungal Dioxafenestrane Sesquiterpenes by the Cooperation of Distinctive Baeyer-Villiger Monooxygenases and α-Ketoglutarate-Dependent Dioxygenases. ACS Catal. 2021, 11, 948-957.
10. Zhang, J-M., Wang, H-H., Liu, X., Hu, C-H., Zou, Y.* Heterologous and Engineered Biosynthesis of Nematocidal Polyketide-Nonribosomal Peptide Hybrid Macrolactone from Extreme Thermophilic Fungi. J. Am. Chem. Soc. 2020, 142, 1957-1965.
11. Zeng, H-C., Yin, G-P., Wei, Q., Li, D-H., Wang, Y., Hu, Y-C., Hu, C-H.*, Zou, Y.* Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis. Angew. Chem. Int. Ed. 2019, 58, 6569-6573. (Hot off the Press, Nat. Prod. Rep., 2019, 36, 1039-1043.)
12. Feng, C., Wei, Q., Hu, C-H.*, Zou, Y.* Biosynthesis of Diphenyl Ethers in Fungi. Org. Lett. 2019, 21, 3114-3118.
13. Chen, X-W., Wang, L., Zhang, J-M., Jiang, T., Hu, C-H., Li, D-H.*, Zou, Y.* Immunosuppressant Mycophenolic Acid Biosynthesis Employs a New Globin-like Enzyme for Prenyl Side Chain Cleavage. Acta. Pharm. Sin. B. 2019, 9, 1253-1258.
@ 独立建组之前的工作 (Prior to SWU)：
14. Zou, Y., Garcia-Borràs, M., Tang, M-C., Hirayama, Y., Li, D., Li, L., Watanabe, K., Houk, K. N.*, Tang, Y.* Enzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis. Nat. Chem. Biol. 2017, 13, 325-332. (Recommended as the exceptional paper by F1000 Prime)
15. Tang, M-C.#, Zou, Y.#, Watanabe, K., Walsh, C. T.*, Tang, Y.* Oxidative Cyclization in Natural Product Biosynthesis. Chem. Rev. 2017, 117, 5226-5333. (#co-first author, web of science, most-cited papers)
14. Zou, Y., Zhan, Z., Li, D., Tang, M-C., Cacho, R., Watanabe, K., Tang, Y.* Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids. J. Am. Chem. Soc. 2015, 137, 4980-4983. (Hot off the Press, Nat. Prod. Rep. 2015, 32, 1165-1169.)
16. Zou, Y.#, Xu, W.#, Tsunematsu, Y., Tang, M-C., Watanabe, K., Tang, Y.* Methylation-Dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis. Org. Lett. 2014, 16, 6390-6393. (#co-first author)
17. Zou, Y., Fang, Q., Yin, H., Liang, Z., Kong, D., Bai, L., Deng, Z., Lin, S.* Stereospecific Biosynthesis of β-Methyltryptophan from l-Tryptophan Features a Stereochemical Switch. Angew. Chem. Int. Ed. 2013, 52, 12951-12955.
18. Zou, Y., Yin, H., Kong, D., Deng, Z., Lin, S.* A Trans-acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248. ChemBioChem 2013, 14, 679-683.
19. Tang, M-C.#, Zou, Y.#, Yee, D., Tang, Y.* Identification of the Pyranonigrin A Biosynthetic Gene Cluster by Genome Mining in Penicillium thymicola IBT 5891. AIChE Journal. 2018, 64, 4182-4186. (#co-first author)
20. Yan, D-J., Chen, Q-B., Gao, J., Bai, J., Liu, B-Y., Zhang, Y-L., Zhang, L., Zhang, C., Zou, Y., Hu, Y-C.* Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids. Org. Lett. 2019, 21, 1475-1479.
21. Huang, T., Duan, Y., Zou, Y., Deng, Z., Lin, S.* NRPS Protein MarQ Catalyzes Flexible Adenylation and Specific S-Methylation. ACS Chem. Biol. 2018, 13, 2387-2391.
22. Duan, Y., Liu, Y., Huang, T., Zou, Y., Huang, T., Hu, K., Deng, Z., Lin, S.* Divergent Biosynthesis of Indole Alkaloids FR900452 and Spiro-maremycins. Org. Biomol. Chem. 2018, 16, 5446-5451.
23. Bai, J., Yan, D., Zhang, T., Guo, Y, Liu, Y., Zou, Y., Tang, M-C., Liu, B., Wu, Q., Yu, S.*, Tang, Y.*, Hu, Y-C.* A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angew. Chem. Int. Ed. 2017, 56, 4782-4786.
24. Zhang, Y., Zou, Y., Brock, N. L., Huang, T., Lan, Y., Wang, X., Deng, Z., Tang, Y., Lin, S.* Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J. Am. Chem. Soc. 2017, 139, 11887-11894.
25. Liu, N., Hung, Y., Gao, S-S., Hang, L., Zou, Y., Chooi, Y-H.*, Tang, Y.* Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. Org. Lett. 2017, 19, 3560-3563.
26. Yu, X., Liu, F., Zou, Y., Tang, M-C., Hang, L., Houk, K. N.*, Tang, Y.* Biosynthesis of Strained Piperazine Alkaloids- Uncovering the Concise Pathway of Herquline A. J. Am. Chem. Soc. 2016, 138, 13529-13532.
27. Li, L., Yu, P., Tang, M-C., Zou, Y., Gao S-S., Hung, Y-S., Zhao, M-X., Watanabe, K., Houk, K. N.*, Tang, Y.* Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase. J. Am. Chem. Soc. 2016, 138, 15837-15840.
28. Han, M.#, Yin, H.#, Zou, Y., Brock, N. L., Huang, T., Deng, Z., Chu, Y.*, Lin, S.* An Acyl Transfer Reaction Catalyzed by an Epimerase MarH. ACS Catal. 2016, 6, 788-792. (#co-first author)
29. Lan, Y., Zou, Y., Huang, T., Wang, X., Brock, N. L., Deng, Z., Lin, S.* Indole Methylation Protects Diketopiperazine Configuration in the Maremycin Biosynthetic Pathway. Sci. China. Chem. 2016, 59, 1224-1228.
30. Kong, D., Zou, Y., Zhang, Z., Xu, F., Brock, N. L., Zhang, L., Deng, Z., Lin, S.* Identification of (2S,3S)-β-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin. Sci. Rep. 2016, 6, 20273.
31. Tang, M-C., Lin, H-C., Li, D., Zou, Y., Li, J., Xu, W., Cacho, R. A., Hillenmeyer, M., Garg, N. K., Tang, Y.* Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. J. Am. Chem. Soc. 2015, 137, 13724-13727.
